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Stable CAAC-based Ruthenium Complexes for Dynamic Olefin Metathesis Under Mild Conditions

submitted on 18.01.2021, 19:15 and posted on 20.01.2021, 05:18 by Oleksandr Kravchenko, Brian J.J. Timmer, Maurice Biedermann, Andrew Kentaro Inge, Olof Ramstrom

A series of olefin metathesis catalysts bearing cyclic (alkyl)(amino)carbene (CAAC) ligands of varying size and steric demand has been synthesized and evaluated in ring-closing-, self-, and cross-metathesis reactions at room temperature. The catalysts were also probed for potential applications in dynamic covalent chemistry. The majority of the catalysts showed high stability, and remained active in the reaction mixtures for several days, including in methanol-based solutions. Higher temperatures could be used to control the reactivity towards sterically challenging substrates, enabling formation of tetrasubstituted olefins. The CAAC complexes exhibited remarkable functional group tolerance towards heteroaromatic and nucleophilic additives, making them potentially useful in the screening of biologically active compounds.


Email Address of Submitting Author


University of Massachusetts Lowell


United States

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest