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Squeezing out the Catalysts: The Disulphide Bond Exchange in Aryl Disulphides at High Hydrostatic Pressure
preprintrevised on 02.11.2020, 15:30 and posted on 03.11.2020, 09:45 by Szymon Sobczak, Paulina Ratajczyk, Andrzej Katrusiak
Exchange of the disulphide bond is a prominent example of equilibrium reactions. Therefore, the wide library of disulphide exchange reactions requires the application of catalysts, such as reducing agents, strong bases, ultraviolet light, or ultrasounds to stimulate higher conversion yields. We employed the pressure between 100 and 400 MPa, for promoting the exchange reactions between various homodimeric aryl disulphides and for optimized conditions obtained 100 % yields and pure single-crystal form of the heterodimer. The reactions were performed in a diamond-anvil cell, as well as in a hydraulic piston-and-cylinder press, and the products were characterized by X-ray diffraction, mass and NMR spectroscopy.
The influence of high pressure and high temperature on the formation of covalent bonds
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