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Manucript.pdf (1.23 MB)
Squeezing out the Catalysts: The Disulphide Bond Exchange in Aryl Disulphides at High Hydrostatic Pressure
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Exchange of the disulphide bond is a prominent example
of equilibrium reactions. Therefore, the wide library of disulphide exchange
reactions requires the application of catalysts, such as reducing agents,
strong bases, ultraviolet light, or ultrasounds to stimulate higher conversion
yields. We employed the pressure between 100 and 400 MPa, for promoting the exchange
reactions between various homodimeric aryl disulphides and for optimized
conditions obtained 100 % yields and pure single-crystal form of the heterodimer.
The reactions were performed in a diamond-anvil cell, as well as in a hydraulic
piston-and-cylinder press, and the products were characterized by X-ray
diffraction, mass and NMR spectroscopy.