These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2 files

Spirocyclizative Remote Arylcarboxylation of Non-Activated Arenes with CO2 via Visible-Light-Induced Reductive Dearomatization

submitted on 19.04.2021, 18:26 and posted on 20.04.2021, 13:02 by yuzhen gao, Hao Wang, Zhuomin Chi, Lei Yang, Chunlin Zhou, Gang Li
Visible-light-induced reductive dearomatization of non-activated arenes is a very challenging transformation and remains in its infancy. Herein, we report a novel strategy to achieve a visible-light-induced spirocyclizative remote arylcarboxylation of non-activated arenes including naphthalenyl- and phenyl-bearing aromatics with CO2 under mild conditions through a radical-polar crossover cascade (RPCC). This reductive dearomatization protocol rapidly delivers a broad range of spirocyclic and valuable carboxylic acid derivatives from readily accessible aromatic precursors with generally good regioselectivity and chemoselectivity.


Email Address of Submitting Author


Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences



ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no conflict of interest.