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Spirocyclizative Remote Arylcarboxylation of Non-Activated Arenes with CO2 via Visible-Light-Induced Reductive Dearomatization
preprintsubmitted on 19.04.2021, 18:26 and posted on 20.04.2021, 13:02 by yuzhen gao, Hao Wang, Zhuomin Chi, Lei Yang, Chunlin Zhou, Gang Li
Visible-light-induced reductive dearomatization of non-activated arenes is a very challenging transformation and remains in its infancy. Herein, we report a novel strategy to achieve a visible-light-induced spirocyclizative remote arylcarboxylation of non-activated arenes including naphthalenyl- and phenyl-bearing aromatics with CO2 under mild conditions through a radical-polar crossover cascade (RPCC). This reductive dearomatization protocol rapidly delivers a broad range of spirocyclic and valuable carboxylic acid derivatives from readily accessible aromatic precursors with generally good regioselectivity and chemoselectivity.