Specific and Rapid SARS-CoV-2 Identification Based on LC-MS/MS Analysis

07 October 2020, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This study describes the development of a novel assay for SARS-CoV-2 identification using LC-MS/MS analysis. A multi-step procedure for the rational down-selection of a set of markers has leaded to the discovery of six SARS-CoV-2 specific and sensitive markers, enabling the reliable identification of the virus. A rapid and simple assay was developed, successfully applied to clinical nasopharyngeal samples. The assay may potentially serve as a complementary approach for SARS-CoV-2 identification.

Keywords

SARS-CoV-2
identification method
LC-MS/MS
Spike
Nucleoprotein
marker

Supplementary materials

Title
Description
Actions
Title
abstract figure
Description
Actions
Title
figure 1
Description
Actions
Title
figure 2
Description
Actions
Title
figure 3
Description
Actions
Title
figure 4
Description
Actions
Title
table 1
Description
Actions
Title
table 2
Description
Actions
Title
table 3
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.