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Solvent- and catalyst-free aza-Michael addition of imidazoles and related heterocycles

preprint
revised on 05.03.2020 and posted on 06.03.2020 by Katharina Kodolitsch, Florian Gobec, Christian Slugovc
This work demonstrates the scope and limitations of the aza-Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent- and catalyst-free conditions. The reaction proceeds at 80°C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been used in small excess. Workup only comprises evaporation of surplus Michael-acceptor and no additional solvents are necessary for purifying the products.

Funding

Technische Universität Graz LP-03

Christian Doppler Laboratory for Organocatalysis in Polymerization

History

Email Address of Submitting Author

slugovc@tugraz.at

Institution

Technische Universität Graz

Country

Austria

ORCID For Submitting Author

0000-0003-1873-5200

Declaration of Conflict of Interest

The authors declare that there is no conflict of interest.

Version Notes

Some minor mistakes corrected; additional data in the supporting info provided.

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Read the published paper

in European Journal of Organic Chemistry

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