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Solvation Effects Drive the Selectivity in Diels-Alder Reaction Under Hyperbaric Conditions

submitted on 09.03.2020, 16:50 and posted on 10.03.2020, 11:29 by Daniele Loco, Riccardo Spezia, François Cartier, Isabelle Chataigner, Jean-Philip Piquemal
High pressure effects on the Diels-Alder reaction in condensed phase are investigated by means oftheoretical methods, employing advanced multiscale modeling approaches based on physically groundedmodels. The simulations reveal how the increase of pressure from 1 to 10000 atm does not affect thestability of the reaction products, modifying the kinetics of the process by lowering considerably thetransition state energy. The reaction profile at high pressure remarkably differs from that at 1 atm,showing a submerged TS and a pre–TS structure lower in energy. The different solvation between endoand exo pre–TS is revealed as the driving force pushing the reaction toward a much higher preferencefor the endo product at high pressure.


Euro-pean Research Council (ERC) under the EuropeanUnion’s Horizon 2020 research and innovation pro-gram (grant agreement No 810367), project EMC2


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Sorbonne Université



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Declaration of Conflict of Interest

no conflict of interest