ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Software - final.pdf (1.9 MB)
0/0

Software for the Analysis and Interpretation of Native Mass Spectrometry Data

preprint
submitted on 23.12.2019 and posted on 24.12.2019 by Timothy Allison, Perdita Barran, Justin Benesch, Sarah Cianferani, Matteo Degiacomi, Valerie Gabelica, Rita Grandori, Erik Marklund, Thomas Menneteau, Lukasz Migas, Argyris Politis, Michal Sharon, Frank Sobott, Konstantinos Thalassinos

The last few years have seen a dramatic increase in applications of native mass and ion mobility spectrometry, especially for the study of proteins and protein complexes. This increase has been catalysed by the availability of commercial instrumentation capable of carrying out such analyses. Like in most fields, however, the software to process the data generated from new instrumentation lags behind. Recently, a number of research groups have started addressing this by developing software, but further improvements are still required in order to realise the full potential of the datasets generated. Here we describe practical aspects as well as challenges in processing native mass spectrometry (MS) and ion mobility-MS datasets, and provide a brief overview of currently available tools. We then set out our vision of future developments that would bring the community together and lead to the development of a common platform to expedite future computational developments, provide standardised processing approaches and serve as a location for the deposition of data for this emerging field.

Funding

EU COST Action BM1403

History

Email Address of Submitting Author

justin.benesch@chem.ox.ac.uk

Institution

University of Oxford

Country

United Kingdom

ORCID For Submitting Author

0000-0002-1507-3742

Declaration of Conflict of Interest

No conflict of interest

Exports