ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2019.10.09_combined.docx.pdf (1.18 MB)
0/0

Small Molecule NF-kB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

preprint
submitted on 24.10.2019 and posted on 28.10.2019 by Brittany Moser, Yoseline Escalante-Buendia, Rachel C. Steinhardt, Matthew Rosenberger, Britteny Cassaidy, Nihesh Naorem, Alfred C. Chon, Minh nguyen, Ngoctran Tran, Aaron Esser-Kahn

Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-a and IL-6. Here we present small molecule NF-kB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.

History

Email Address of Submitting Author

aesserkahn@uchicago.edu

Institution

University of Chicago

Country

United States

ORCID For Submitting Author

0000-0003-1273-0951

Declaration of Conflict of Interest

No conflict of interest.

Exports