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Single Amino Acid Based Self-Assemblies of Cysteine and Methionine

preprint
revised on 26.05.2018 and posted on 29.05.2018 by Nidhi Gour, Bharti Koshti, Chandra Kanth P., Dhruvi Shah, Vivek Shinh Kshatriya, Reena Agrawal-Rajput, Manoj Pandey
We report for the very first time self-assembly of Cysteine and Methionine to discrenible strucutres under neutral condition. The nature of interactions which lead to such self-assemblies was purported by coincubating assemblies in urea and mercaptoethanol. Further interaction of aggregates with short amyloidogenic dipeptide diphenylalanine (FF) was assessed. While cysteine aggregates completely disrupted FF fibres, methionine albeit triggered fibrillation. . The results presented in the manuscript are striking, since to the best of our knowledge,this is the first report which demonstrates that even non-aromatic amino acids (cysteine and methionine) can undergo spontaneous self-assembly to form ordered aggregates.

Funding

DST SERB EMR/2016/003186

History

Email Address of Submitting Author

nidhi.gour@iar.ac.in

Institution

Indian Institute of Advanced Research

Country

India

ORCID For Submitting Author

0000-0003-2479-2113

Declaration of Conflict of Interest

There are no conflicts of interest to declare.

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