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Single Amino Acid Based Self-Assemblies of Cysteine and Methionine
preprintrevised on 26.05.2018, 06:13 and posted on 29.05.2018, 13:45 by Nidhi Gour, Bharti Koshti, Chandra Kanth P., Dhruvi Shah, Vivek Shinh Kshatriya, Reena Agrawal-Rajput, Manoj Pandey
We report for the very first time self-assembly of Cysteine and Methionine to discrenible strucutres under neutral condition. The nature of interactions which lead to such self-assemblies was purported by coincubating assemblies in urea and mercaptoethanol. Further interaction of aggregates with short amyloidogenic dipeptide diphenylalanine (FF) was assessed. While cysteine aggregates completely disrupted FF fibres, methionine albeit triggered fibrillation. . The results presented in the manuscript are striking, since to the best of our knowledge,this is the first report which demonstrates that even non-aromatic amino acids (cysteine and methionine) can undergo spontaneous self-assembly to form ordered aggregates.
Read the published paper
in ACS Chemical Neuroscience