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revised on 26.05.2018 and posted on 29.05.2018by Nidhi Gour, Bharti Koshti, Chandra Kanth P., Dhruvi Shah, Vivek Shinh Kshatriya, Reena Agrawal-Rajput, Manoj Pandey
We report for the very first time self-assembly
of Cysteine and Methionine to discrenible strucutres under neutral condition. The nature of interactions which lead to such
self-assemblies was purported by coincubating assemblies in urea and
mercaptoethanol. Further interaction of aggregates with short amyloidogenic
dipeptide diphenylalanine (FF) was assessed. While cysteine aggregates
completely disrupted FF fibres, methionine albeit triggered fibrillation. . The results presented in the manuscript are
striking, since to the best of our knowledge,this is the first report which
demonstrates that even non-aromatic amino acids (cysteine and methionine) can
undergo spontaneous self-assembly to form ordered aggregates.