These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 07.08.2020 and posted on 10.08.2020by Shuli Tang, Xin Yan
present an on-demand electrochemical mass spectrometry workflow for lipid
structural characterization with the capability of identifying double-bond and sn-positional
isomers. Two voltage-controlled
electrochemical reactions, interfacial electro-epoxidation and anodic corrosion
of a cobalt electrode, are cascaded in this strategy. The epoxidized products and
Co-adducted ions of lipids are fragmented in tandem MS to generate structure
characteristic fragments that indicate double-bond and sn-positions. The
unique feature of this workflow lies in the sequential localization of double
bonds, elucidation of sn-positions,
and collection of native lipid information in a single system and simply by tuning
ESI voltages. This feature, as well as low sample consumption, no need for
extra apparatus, and quantitative analysis, should allow wide applications in the