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Silicon-Vacancy Nanodiamonds as High Performance Near-Infrared Emitters for Live-Cell Dual-Color Imaging

revised on 02.02.2021, 12:32 and posted on 03.02.2021, 08:07 by Weina Liu, Yan Liu, Viatcheslav N. Agafonov, Haoyuan Qi, Kaloian Koynov, Valery A. Davydov, Rustem Uzbekov, Ute Kaiser, Theo Lasser, Fedor Jelezko, Tanja Weil
Intracellular imaging is limited by a short bleaching time of fluorescent molecules and particles. In our work we used nanodiamonds with silicon-vacancy centers (SiV) obtained by high-pressure high-temperature synthesis based on metal-catalyst-free growth. They are coated with a polypeptide biopolymer that allows efficient cellular uptake. Our results demonstrate that high photostability and narrow emission in the near-infrared region of nanodiamonds with SiV allow live-cell dual-color imaging and intracellular tracking. Such a system has broad potential applications, which is not limited to live-cell bioimaging, but also include diagnostic (SiV as a nanosized thermometer) and theranostic (nanodiamonds as drug carrier).


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ERC Synergy Grant 319130 - BioQ

Russian Foundation for Basic Research 18-03-00936


Email Address of Submitting Author


Max Planck Institute for Polymer Research



ORCID For Submitting Author


Declaration of Conflict of Interest

There is no conflict of interest

Version Notes

Version 2.0