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ddt_corr.pdf (4.11 MB)

Shotgun Drug Repurposing Biotechnology to Tackle Epidemics and Pandemics

preprint
revised on 02.05.2020 and posted on 04.05.2020 by William Mangione, Zackary Falls, Thomas Melendy, Gaurav Chopra, Ram Samudrala
In this manuscript we highlight consensus between the list of drugs currently in clinical trials to treat COVID-19, the worldwide pandemic caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), and the list of predictions made using our shotgun drug discovery, repurposing, and design platform known as CANDO (Computational Analysis of Novel Drug Opportunities). We make the argument that increased funding and development for drug repurposing biotechnology like ours will help combat the inevitable pathogenic outbreaks of the future.

Funding

NOVEL PARADIGMS FOR DRUG DISCOVERY: COMPUTATIONAL MULTITARGET SCREENING

Office of the Director

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University of Buffalo Clinical and Translational Science Institute

National Center for Advancing Translational Sciences

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Buffalo Research Innovation in Genomic and Healthcare Technology Education (BRIGHT Education)

United States National Library of Medicine

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Indiana Clinical and Translational Sciences Institute

National Center for Advancing Translational Sciences

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Cancer Center Support Grant

National Cancer Institute

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History

Email Address of Submitting Author

rams@buffalo.edu

Institution

University at Buffalo

Country

USA

ORCID For Submitting Author

0000-0001-9069-8497

Declaration of Conflict of Interest

The authors declare no conflicts of interest.

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