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IR140Jaggregates_ChemRxiv.pdf (1.11 MB)

Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

preprint
submitted on 22.12.2018, 05:58 and posted on 26.12.2018, 14:59 by Wei Chen, ChiAn Cheng, Emily Cosco, Shyam Ramakrishnan, Jakob Lingg, Oliver Bruns, Jeffrey I. Zink, Ellen Sletten
Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivowith 980 nm excitation.

Funding

NSF GFRP DGE-1144087

Emmy-Noether-Programm of DRG BR 5355/2-1

Helmholtz Pioneer Campus Institute for Biomedical Engineering

Zink student research fund

Sloan Research Award FG-2018-10855

UCLA

History

Email Address of Submitting Author

sletten@chem.ucla.edu

Institution

University of California, Los Angeles

Country

United States

ORCID For Submitting Author

0000-0002-0049-7278

Declaration of Conflict of Interest

The authors have no conflicts of interest to declare.

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