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Sequence Analysis and Structure Prediction of SARS-CoV-2 Accessory Proteins 9b and ORF14: Evolutionary Analysis Indicates Close Relatedness to Bat Coronavirus

preprint
submitted on 05.06.2020 and posted on 08.06.2020 by CHITTARANJAN BARUAH, PAPARI DEVI, DHIRENDRA K SHARMA

This paper has attempted into the structure prediction and functional analysis of two such accessory proteins, 9b and ORF14, in the absence of experimental structures. Sequence analysis, structure prediction, functional characterization, and evolutionary analysis based on the UniProtKB reviewed the amino acid sequences of SARS-CoV-2 9b (P0DTD2) and ORF14 (P0DTD3) proteins. Modeling has been presented with the introduction of hybrid comparative and ab-initio modeling. The evolutionary analysis of both the proteins of human SARS-CoV-2 indicates close relatedness to the bat coronavirus.

Funding

NONE

History

Email Address of Submitting Author

chittaranjan_21@yahoo.co.in

Institution

POST GRADUATE DEPARTMENT OF ZOOLOGY, DARRANG COLLEGE, TEZPUR, ASSAM

Country

India

ORCID For Submitting Author

0000-0001-7030-7567

Declaration of Conflict of Interest

NONE

Version Notes

FIRST VERSION

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