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GEM micelles.pdf (2.96 MB)

Self-assembled Dendritic Boronate Micelles as a Promising Delivery Strategy for Gemcitabine

preprint
submitted on 12.11.2020, 22:30 and posted on 18.01.2021, 05:09 by Muna A. Al-Ni’mat, Samuel Parcero-Bouzas, Sandra P. Amaral, Eduardo Fernandez-Megia

A novel drug delivery system is described based on a PEG-dendritic copolymer functionalized with peripheral boronic acids, that self-assembles in the presence of catechol to afford nanometric micelles with the ability to encapsulate GEM. The simplicity of the method, with all equilibria (boronate esterification, copolymer self-assemble, drug encapsulation) occurring simultaneously, is compatible with a high tunability of the micelle properties (via diol structure and the boronic acid-to-diol molar ratio).

Funding

RTI2018-102212-B-I00

ED431C 2018/30

ED431G2019/03

History

Email Address of Submitting Author

ef.megia@usc.es

Institution

Universidade de Santiago de Compostela

Country

Spain

ORCID For Submitting Author

0000-0002-0405-4933

Declaration of Conflict of Interest

No conflict of interest

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