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Self-Healing Injectable Polymer Hydrogel via Dynamic Thiol-Alkynone Double Addition Crosslinks

preprint
submitted on 28.02.2020 and posted on 28.02.2020 by bowen fan, Kai Zhang, Qian Liu, Rienk Eelkema

Introduction of dynamic thiol-alkynone double addition crosslinks in a polymer network enable the formation of a self-healing injectable polymer hydrogel. A 4-arm polyethylene glycol (PEG) tetra-thiol star polymer is crosslinked by a small molecule alkynone via the thiol-alkynone double adduct, to generate a hydrogel network under ambient aqueous conditions (buffer pH=7.4 or 8.2, room temperature). The mechanical properties of these hydrogels can be easily tuned by varying the concentration of polymer precursors. Through the dynamic thiol-alkynone double addition crosslink, these hydrogels are self-healing and shear thinning, as demonstrated by rheological measurements, macroscopic self-healing and injection tests. These hydrogels can be injected through a 20G syringe needle and recover after extrusion. In addition, good cytocompatibility of these hydrogels is confirmed by cytotoxicity test. This work shows the application of a new type of dynamic covalent chemistry in the straightforward preparation of self-healing injectable hydrogels, which may find future biomedical applications such as tissue engineering and drug delivery.

Funding

ERC Consolidator Grant 726381

History

Email Address of Submitting Author

r.eelkema@tudelft.nl

Institution

Delft University of Technology

Country

Netherlands

ORCID For Submitting Author

0000-0002-2626-6371

Declaration of Conflict of Interest

no conflict declared

Version Notes

pre-submission version

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