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Singlet Oxygen (Preprint).pdf (1002.76 kB)

Selective Generation of Singlet Oxygen in Chloride Accelerated Copper Fenton Chemistry

submitted on 20.11.2018, 13:37 and posted on 20.11.2018, 15:26 by Andrew Carrier, Collins Nganou, David Oakley, Yongli Chen, Ken Oakes, Stephanie MacQuarrie, Xu Zhang

Singlet oxygen (1O2), a widely used reactive oxygen species (ROS) in industry and biomedical applications, plays a fundamental role throughout nature. We report a novel method to generate 1O2selectively and efficiently through copper-based Fenton chemistry under circumneutral conditions enhanced by chloride as co-catalyst, with reactivity completely different than that observed in classical iron-based Fenton chemistry. The mechanism of its formation was elucidated through the kinetic studies of orthogonally reactive reporter molecules, i.e., singlet oxygen sensor green, 4-hydroxy-2,2,6,6-tetramethylpiperidine, and phenol, and selective ROS quenchers. This method selectively generates 1O2in situneither relying on photosensitization nor resulting in side reactions, and together with the mechanistic understanding of the Cu-Fenton reaction, not only opens new possibilities in many industries, such as organic synthesis and antimicrobial treatments, but also provides insight into Cu and H2O2containing chemical, environmental, and biological systems.


Atlantic Canada Opportunities Agency

Nova Scotia Lands

Cape Breton University

Natural Sciences and Engineering Research Council of Canada

Beatrice Hunter Cancer Research Institute

Guangdong Province Higher Vocational College & School’s Pearl River Scholar Funded Scheme


Email Address of Submitting Author


Cape Breton University



ORCID For Submitting Author


Declaration of Conflict of Interest

There are no conflicts of interest to report.