Selective Generation of Singlet Oxygen in Chloride Accelerated Copper Fenton Chemistry
Singlet oxygen (1O2), a widely used reactive oxygen species (ROS) in industry and biomedical applications, plays a fundamental role throughout nature. We report a novel method to generate 1O2selectively and efficiently through copper-based Fenton chemistry under circumneutral conditions enhanced by chloride as co-catalyst, with reactivity completely different than that observed in classical iron-based Fenton chemistry. The mechanism of its formation was elucidated through the kinetic studies of orthogonally reactive reporter molecules, i.e., singlet oxygen sensor green, 4-hydroxy-2,2,6,6-tetramethylpiperidine, and phenol, and selective ROS quenchers. This method selectively generates 1O2in situneither relying on photosensitization nor resulting in side reactions, and together with the mechanistic understanding of the Cu-Fenton reaction, not only opens new possibilities in many industries, such as organic synthesis and antimicrobial treatments, but also provides insight into Cu and H2O2containing chemical, environmental, and biological systems.
Atlantic Canada Opportunities Agency
Nova Scotia Lands
Cape Breton University
Natural Sciences and Engineering Research Council of Canada
Beatrice Hunter Cancer Research Institute
Guangdong Province Higher Vocational College & School’s Pearl River Scholar Funded Scheme