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Saturation Transfer Difference NMR Spectroscopy Using Glycopolymers

preprint
submitted on 28.10.2020, 14:54 and posted on 29.10.2020, 10:33 by janet muzulu, Amit Basu

We report the use of Saturation Transfer Difference (STD) NMR spectroscopy to observe the interaction of various phenylboronic acids (PBAs) with synthetic glycopolymers presenting galactose and glucose. After optimizing experimental parameters to maximize spin diffusion, the binding of boronic acids to the glycopolymers was examined using STD NMR. Efficient amplification factor build-up curves which were used to generate an epitope map for the boronic acid binding to the glycopolymers. STD-NMR was also used to detect the interaction between indole and a galactosylated glycopolymer, providing an indole-based view of this C-H – π interaction.

Funding

NSF CHE1607554

History

Email Address of Submitting Author

amit_basu@brown.edu

Institution

Brown University

Country

United States

ORCID For Submitting Author

0000-0001-6312-675X

Declaration of Conflict of Interest

No conflict of interest

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