S(IV)–Mediated Unsymmetrical Heterocycle Cross-Couplings
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report a sulfur (IV) mediated cross-coupling for facile synthesis of heteroaromatic
substrates. Addition of heteroaryl nucleophiles onto a simple,
readily-accessible alkyl sulfinyl (IV) chloride allows formation of a trigonal
bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl
products in a practical and efficient fashion.