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S(IV)–Mediated Unsymmetrical Heterocycle Cross-Couplings

preprint
submitted on 03.12.2019 and posted on 11.12.2019 by Min Zhou, Jet Tsien, Tian Qin

Herein we report a sulfur (IV) mediated cross-coupling for facile synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles onto a simple, readily-accessible alkyl sulfinyl (IV) chloride allows formation of a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion.

History

Email Address of Submitting Author

Tian.Qin@UTSouthwestern.edu

Institution

UT Southwestern Medical Center

Country

United States

ORCID For Submitting Author

0000-0001-7225-3224

Declaration of Conflict of Interest

no conflict of interest

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