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Structural_COVID_2021_edited.pdf (4.3 MB)

SARS-CoV-2 Mutations in Brazil: From Genomics to Clinical Conditions

preprint
submitted on 17.02.2021, 10:30 and posted on 19.02.2021, 07:43 by Luis Timmers, Julia Peixoto, Rodrigo Ducati, Jose Fernando Bachega, Leandro Mattos Pereira, Rafael Andrade Caceres, Fernanda Majolo, Guilherme Liberato Da Silva, Debora Bublitz Anton, Marcia Inês Goettert, Odir Antônio Dellagostin, Joao Henriques, Leder Xavier, Stefan Laufer
Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter, being a reference region to monitor how SARS-CoV-2 is mutating and spreading. Here, we combined genomic and structural biology analysis evaluate genomes isolated from different regions of Brazil. We showed that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, helping studies of structure-based drug discovery and vaccine development.

Funding

CNPq, grant number: 407537/2018

CAPES, Grant: Edital nº 09/2020

History

Email Address of Submitting Author

stefan.laufer@uni-tuebingen.de

Institution

University of Tuebingen

Country

Germany

ORCID For Submitting Author

0000-0001-6952-1486

Declaration of Conflict of Interest

none

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ChemRxiv

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