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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule
preprintsubmitted on 17.11.2020, 20:19 and posted on 18.11.2020, 12:32 by Timothy Kench, Peter A. Summers, Marina K. Kuimova, James Lewis, Ramon Vilar
In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.