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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

preprint
submitted on 17.11.2020, 20:19 and posted on 18.11.2020, 12:32 by Timothy Kench, Peter A. Summers, Marina K. Kuimova, James Lewis, Ramon Vilar
In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

History

Email Address of Submitting Author

r.vilar@imperial.ac.uk

Institution

Imperial College London

Country

United Kingdom

ORCID For Submitting Author

0000-0003-2992-199X

Declaration of Conflict of Interest

No conflict of interest

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