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Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

submitted on 17.11.2020, 20:19 and posted on 18.11.2020, 12:32 by Timothy Kench, Peter A. Summers, Marina K. Kuimova, James Lewis, Ramon Vilar
In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.


Email Address of Submitting Author


Imperial College London


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest