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Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes..docx (492.02 kB)
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Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes

preprint
submitted on 01.04.2020 and posted on 02.04.2020 by Yuvraj Bhujbal, kamlesh vadagaonkar, santosh kori, Anant Kapdi
A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as the reaction solvent has been presented herewith. An in-situ one-pot sequential HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.

History

Email Address of Submitting Author

ar.kapdi@ictmumbai.edu.in

Institution

Institute of Chemical Technology

Country

India

ORCID For Submitting Author

0000-0001-9710-8146

Declaration of Conflict of Interest

No conflict of interest

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