These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes
preprintsubmitted on 01.04.2020, 05:03 and posted on 02.04.2020, 13:00 by Yuvraj Bhujbal, kamlesh vadagaonkar, santosh kori, Anant Kapdi
A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as the reaction solvent has been presented herewith. An in-situ one-pot sequential HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.