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ChemRxiv.pdf (443.19 kB)
Robust Synthesis of NIR-Emissive P-Rhodamine Fluorophores
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accessed by implementing a robust three step sequence consisting of (i) addition of m-metallated anilines
to dichlorophosphine oxides, (ii)
selective dibromination, and (iii)
cyclization of the diaryllithium reagents derived from the dibromides to form
the dihydroacridophosphine core of P-rhodamines. A modified route to produce
non-symmetric P-rhodamines was additionally developed. A library of the prepared
P-rhodamines provides first insight into dependence of fluorophore properties
on the structure of P-rhodamines. A P-rhodamine with highest batochromic shifts
and quantum yields in the class was identified.