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Rh(III)-Catalyzed Direct Access to 2,3-Substituted β-N-Glycosyl Indoles Through C-H Activation/annulation Coupling of β-N-Aryl Glycosides with Substituted Internal Alkynes
preprintsubmitted on 23.10.2019, 18:56 and posted on 29.10.2019, 20:40 by Samir Messaoudi, Olivier Provot, Mouad Alami, Guangkuan Zhao, Mingxiang Zhu
An efficient and selective C-H activation/annulation of readily available β-N-aryl glycosides with various alkynes has been established. Using [Cp*RhCl2]2 as a catalyst and AgSbF6 in DCE, this protocol proved to be general to prepare a variety of 2,3-substituted N-glycosyl indoles in good yields with exclusive β-selectivity.
Carbohydrates Nucleophiles, New Partners in Transition Metals Catalysis – CarNuCat
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