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Rh2(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins using Nonactivated N-Atom Precursors

preprint
submitted on 19.05.2021, 21:36 and posted on 24.05.2021, 04:43 by Wrickban Mazumdar, Tianning Deng, Yuki Yoshinaga, Pooja B. Patel, Dana Malo, Tala Malo, Donald Wink, Tom Driver
The development of the first intermolecular Rh2(II)-catalyzed aziridination of di-, tri-, or tetraubstituted olefins using aryl- or heteroaryl amines as nonactivated N-atom precursors and an iodine(III) reagent as the stoichiometric oxidant is reported. The Rh2(II)-catalyzed N-atom transfer to the olefin is stereospecific, chemo- and diastereoselective to produce the N-aryl aziridine as the only amination product.

Funding

National Institutes of Health NIGMS GM138388

National Science Foundation CHE-1564959

History

Email Address of Submitting Author

tgd@uic.edu

Institution

University of Illinois at Chicago

Country

United States of America

ORCID For Submitting Author

0000-0001-7001-342X

Declaration of Conflict of Interest

no conflict of interest

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