These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Rh2(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins using Nonactivated N-Atom Precursors
preprintsubmitted on 19.05.2021, 21:36 and posted on 24.05.2021, 04:43 by Wrickban Mazumdar, Tianning Deng, Yuki Yoshinaga, Pooja B. Patel, Dana Malo, Tala Malo, Donald Wink, Tom Driver
The development of the first intermolecular Rh2(II)-catalyzed aziridination of di-, tri-, or tetraubstituted olefins using aryl- or heteroaryl amines as nonactivated N-atom precursors and an iodine(III) reagent as the stoichiometric oxidant is reported. The Rh2(II)-catalyzed N-atom transfer to the olefin is stereospecific, chemo- and diastereoselective to produce the N-aryl aziridine as the only amination product.