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Retrained Generic Antibodies Can Recognize SARS-CoV-2

preprint
submitted on 17.11.2020, 19:23 and posted on 18.11.2020, 12:27 by Yanxiao Han, Katherine McReynolds, Petr Kral
The dramatic impact which novel viruses can have on the human society could be mitigated without the need of vaccination if antibodies present within the population are retrained to recognize these viruses. With this idea in mind, a double-faced peptide-based boosters are computationally designed to allow recognition of SARS-CoV-2 by Hepatitis B antibodies. One booster face is made of ACE2-mimic peptides that can bind to the receptor binding domain (RBD) of SARS-CoV-2. The other booster face is composed of a Hepatitis B core-antigen, targeting the Hepatitis B antibody fragment. Molecular dynamics simulations revealed that the designed boosters have a highly specific and stable binding
both to RBD and the antibody fragment (AF). This approach can provide a cheap and efficient neutralization of emerging pathogens.

Funding

UIC Center for Clinical and Translational Science

History

Email Address of Submitting Author

pkral@uic.edu

Institution

University of Illinois at Chicago

Country

United States

ORCID For Submitting Author

0000-0003-2992-9027

Declaration of Conflict of Interest

no conflict of interest

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