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Repurposing Nonnucleoside Antivirals Against SARS-CoV2 NSP12 (RNA Dependent RNA Polymerase) and Identification of Domain Specific Interactions

preprint
submitted on 27.07.2020 and posted on 27.07.2020 by Feroza Begum, UPASANA RAY

The pandemic of SARS-CoV-2 has necessitated expedited research efforts towards finding potential antiviral targets and drug development measures. While new drug discovery is time consuming, drug repurposing has been a promising area for elaborate virtual screening and identification of existing FDA approved drugs that could possibly be used for targeting against functions of various proteins of SARS-CoV-2 virus. RNA dependent RNA polymerase (RdRp) is an important enzyme for the virus that mediates replication of the viral RNA. Inhibition of RdRp could inhibit viral RNA replication and thus new virus particle production. Here, we screened non-nucleoside antivirals and found three out of them to be strongest in binding to RdRp. We propose these three drugs as potential RdRp inhibitors based on the site of binding.

History

Email Address of Submitting Author

ray.upasana@gmail.com

Institution

CSIR-Indian Institute of Chemical Biology

Country

India

ORCID For Submitting Author

0000-0003-4783-9295

Declaration of Conflict of Interest

No conflict of interest

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