These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Regulating transition metal catalysis through interference by short RNAs copy.pdf (2.86 MB)

Regulating Transition Metal Catalysis Through Interference by Short RNAs

submitted on 11.03.2019, 07:11 and posted on 12.03.2019, 16:49 by Sydnee Green, Hayden Montgomery, Tyler R. Benton, Neil Chan, Hosea Nelson
Here we report the discovery of a Au(I)-DNA hybrid catalyst that is compatible with biological media and whose reactivity can be regulated by small complementary nucleic acid sequences. The development of this catalytic system was enabled by the discovery of a novel Au(I) metal-mediated base pair. We find that Au(I) binds selectively to double stranded DNA containing C–T mismatches. In the Au(I)-DNA catalyst's latent state, the Au(I) ion is sequestered by the mismatch such that it is coordinatively saturated, rendering it catalytically inactive. Upon addition of an RNA or DNA strand that is complementary to the latent catalyst's oligonucleotide backbone, catalytic activity is induced leading to a 7-fold increase in formation of fluorescent product, forged through a Au(I)-catalyzed hydroamination reaction. Further development of this catalytic system will allow for temporal and spatial control of transition metal catalysis through gene transcription.


Pew Charitable Trust, David and Lucile Packard Foundation


Email Address of Submitting Author


University of California, Los Angeles



ORCID For Submitting Author


Declaration of Conflict of Interest

no conflict of interest