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Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

preprint
submitted on 03.03.2019, 18:03 and posted on 04.03.2019, 19:59 by Arumugavel Murugan, Venkata Nagarjuna Babu, Nagaraj Sabarinathan, Sharada Duddu. S
Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Funding

DST-SERB New Delhi, India.

History

Email Address of Submitting Author

sharada@iith.ac.in

Institution

Indian Institute of Technology Hyderabad

Country

India

ORCID For Submitting Author

0000-0001-5861-4126

Declaration of Conflict of Interest

There are no conflicts to declare

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