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revised on 23.06.2020 and posted on 25.06.2020by Marila S. Santos, Martyna Cybularczyk-Cecotka, Burkhard Koenig, Maciej Giedyk
aqueous solutions were employed to engage non-activated alkyl bromides in the
visible-light-promoted C‑H functionalization of heteroarenes. The reactive
carbon-centered alkyl radicals were generated by merging the photoredox
approach, bromide anion co-catalysis and spatial pre-aggregation of reacting
species in the mixture. The presented methodology allowed obtaining alkylated
heteroarenes without stoichiometric radical-promoters, in acid-free conditions
and using blue LEDs as the light source.