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Receptor Determinant Analogues for All 9-O-Ac-Sialoglycan-Recognizing Corona Viruses

preprint
submitted on 04.05.2020 and posted on 07.05.2020 by Pratibha Preeti Maurya

In present study, analogues of receptor determinants were identified, which can mimic 9-O-Acsialoglycan-recognition by viruses and its usage in antiviral. It is well known that receptor determinants are part of host cell surface receptors which are recognized by virus surface glycoprotein as the first interaction of the target cell. This recognition governs the further processes of viral infection. Similar to other influenza viruses, Corona virus also processes through mechanisms of host interaction. This hostvirus interaction involves a conserved domain at interaction component of virus, which is known to be a key component during the process of virus infection. Therefore in the present study profile of possible Pharmacophore of conserved domain was used as a filter to identify analogues of receptor determinant from database ZINC database. The identified molecules were re-observed among the applicability domain defined by existing antiviral drugs as well as natural existing receptor determinant with sialic acid. The identified molecule needs to be further evaluated through in-vitro experiments.

History

Email Address of Submitting Author

ppmcbbe@gmail.com

Institution

Computational Biology for Biochemical Experiments (CBBE), Lucknow-21, India

Country

India

ORCID For Submitting Author

0000-0002-9130-5613

Declaration of Conflict of Interest

no conflict of interest

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