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Reaction of H2 with Mitochondria-Relevant Metabolites Using a Multifunctional Molecular Catalyst

submitted on 17.03.2020, 15:53 and posted on 18.03.2020, 12:13 by Sota Nimura, Shota Yoshioka, Masayuki Naruto, Susumu Saito
The Krebs cycle is the fuel/energy source for cellular activity, and therefore of paramount importance for oxygen-based life. The cycle occurs in the mitochondrial matrix, where it produces and transfers electrons to generate energy-rich NADH and FADH2, as well as C4-, C5-, and C6-polycarboxylic acids as energy-poor metabolites. These metabolites are bio-renewable resources that represent potential sustainable carbon feedstocks, provided that carbon–hydrogen bonds are restored to these molecules. In the present study, polycarboxylic acids of the Krebs cycle and other mitochondria-relevant metabolites are dehydrated and reduced to diols or triols upon reaction with H2, catalyzed by sterically confined iridium-bipyridyl complexes.


Email Address of Submitting Author


Nagoya University



ORCID For Submitting Author


Declaration of Conflict of Interest

Authors declare no competing interests.

Version Notes

1st version