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Rare A-Type, New Spiro-Type, and Highly Oligomeric Proanthocyanidins from Pinus massoniana
preprintsubmitted on 21.04.2020, 20:07 and posted on 24.04.2020, 08:41 by Bin Zhou, Yvette Alania, Mariana C. Reis, James McAlpine, Ana K. Bedran-Russo, Guido Pauli, Shao-Nong Chen
Isolation of underivatized PACs led to three new, structurally unique PACs (1-3) from pine bark. Pinutwindoublin (1) is the first known trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α). Pinuspirotetrin (2) represents the first PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B type hexamer that consists of the tetramer, peanut procyanidin E, and an A-type dimer (5).