ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
PineThreeRareNewPACs_ChemRxiv.pdf (4.55 MB)

Rare A-Type, New Spiro-Type, and Highly Oligomeric Proanthocyanidins from Pinus massoniana

preprint
submitted on 21.04.2020 and posted on 24.04.2020 by Bin Zhou, Yvette Alania, Mariana C. Reis, James McAlpine, Ana K. Bedran-Russo, Guido Pauli, Shao-Nong Chen
Isolation of underivatized PACs led to three new, structurally unique PACs (1-3) from pine bark. Pinutwindoublin (1) is the first known trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α). Pinuspirotetrin (2) represents the first PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B type hexamer that consists of the tetramer, peanut procyanidin E, and an A-type dimer (5).

Funding

NIDCR/NIH R01 DE021040

NIGMS/NIH P41 GM068944

History

Email Address of Submitting Author

sc4sa@uic.edu

Institution

College of Pharmacy, University of Illinois at Chicago

Country

USA

ORCID For Submitting Author

0000-0003-0748-0863

Declaration of Conflict of Interest

No conflict of interest

Licence

Exports