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Rapid Catalyst Capture Enables Metal-Free Parahydrogen-Based Hyperpolarized Contrast Agents

preprint
submitted on 02.04.2018 and posted on 03.04.2018 by Danila Barskiy, Lucia Ke, Xingyang Li, Vincent Stevenson, Nevin Widarman, Hao Zhang, Ashley Truxal, Alexander Pines

Hyperpolarization techniques based on the use of parahydrogen provide orders of magnitude signal enhancement for magnetic resonance spectroscopy and imaging. The main drawback limiting widespread applicability of parahydrogen-based techniques in biomedicine is the presence of organometallic compounds (the polarization transfer catalysts) in solution with hyperpolarized contrast agents. These catalysts are typically complexes of platinum-group metals and their administration in vivo should be avoided.


Herein, we show how extraction of a hyperpolarized compound from an organic phase to an aqueous phase combined with a rapid (less than 10 seconds) Ir-based catalyst capture by metal scavenging agents can produce pure parahydrogen-based hyperpolarized contrast agents as demonstrated by high-resolution nuclear magnetic resonance (NMR) spectroscopy and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The presented methodology enables fast and efficient means of producing pure hyperpolarized aqueous solutions for biomedical and other uses.

Funding

CHE-1709944

History

Email Address of Submitting Author

barskiy@berkeley.edu

Institution

UC Berkeley

Country

USA

ORCID For Submitting Author

0000-0002-2819-7584

Declaration of Conflict of Interest

No conflict of interest

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