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RNA Phosphorothioate Modification in Prokaryotes and Eukaryotes
preprintrevised on 13.01.2020, 15:54 and posted on 14.01.2020, 11:49 by Ying Wu, Yaning Tang, xiaolong dong, Ya Ying Zheng, Phensinee Haruehanroengra, song mao, Qishan Lin, Jia Sheng
We report the first RNA phosphorothioate modification in both prokaryotes and eukaryotes. The GpsG modification exists in the Rp configuration and was quantified with liquid chromatography coupled with tandem mass spectrometry. Furthermore, we show the Dnd clusters that regulate DNA PT modification also play roles in RNA PT modification.
Read the published paper
in ACS Chemical Biology