These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2 files

Quercetin Induces Lipid Domain-Dependent Permeability

revised on 08.04.2021, 13:07 and posted on 08.04.2021, 13:25 by Natalia Slade, Danubia Batista Martins, Marcia P. dos Santos Cabrera
In this work, we present our results on quercetin interaction with distinct model membranes exploring the importance of lipid phases, ld, ld/lo and ld+lo+so, to the action of this flavonoid in bilayers and possibly contributing to clarifying some controversial aspects related to quercetin multiple activities. We found out that quercetin is able to increase membrane permeability in a manner dependent on the presence and characteristics of lipid domains. In the presence of sphingomyelin, we found the greatest increase in mean membrane permeability (at least 10 times higher than the other lipid compositions). We also observed the presence of micrometric domains whose shape and size were disturbed by the action of quercetin. The presence of cholesterol increased membrane rigidity. This effect was enhanced with the presence of quercetin, but for chol-sphingomyelin combination, the bilayers became more flaccid at low quercetin/lipid proportions (< 1/5) and moderately rigid at proportions of the 1/1 order. The affinity parameters were higher for the most homogeneous systems and with larger areas and extensions of disordered liquid phase than for those systems of higher heterogeneity.


Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP Nos. 2012/24259-0, 2014/08372-7, 2014/06713-1, 2014/11877-3

DBM was recepient of CAPES scholarship


Email Address of Submitting Author





ORCID For Submitting Author


Declaration of Conflict of Interest

The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.