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Analysis of ethyl carbamate in distillers grains co-products and bovine plasma by GC-MS.pdf (571.89 kB)

Quantitative Analysis of Ethyl Carbamate in Distillers Grains Co-products and Bovine Plasma by GC-MS

submitted on 02.06.2020, 16:47 and posted on 03.06.2020, 13:23 by Linxing Yao, Kaitlyn Maloley, Corey D. Broeckling, Steve Ensley, Scott Crain, Robert Coffey

ABSTRACT : Ethyl carbamate (EC) is a fermentation byproduct in foods and beverages and classified as a Group 2A probable human carcinogen. Each year greater than 40 million metric tons of fermentation co-products from the U.S. ethanol industry are fed to food animals. A GC-MS assay was developed to analyze EC extracted from various distillers grains co-products with a limit of detection at 0.7 ng/g. EC was detected in all the distillers grains co-products surveyed in this study. Corn condensed distillers solubles contained the highest level of EC ranging from 1618 to 2956 ng/g. The levels of EC in the semi-solid co-products varied from 17 to 917 ng/g. Cattle fed on these fermentation co-products were found to contain 2-3 ng/mL of EC in blood plasma. No EC was detected in control animal blood plasma. The presence of EC in animal feeds and subsequently in animals may pose an animal health risk.


Infectious Disease Research Center - Research Innovation Center, Colorado State University

Veriprime Research Division, Meade, KS


Email Address of Submitting Author


Veriprime Research Division


United States

ORCID For Submitting Author


Declaration of Conflict of Interest

Robert Coffey is a consultant for Veriprime Research Division; Scott Crain is CEO and owner of Veripeime Research Division, Meade, KS

Version Notes

Version 20200601



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in Journal of Agricultural and Food Chemistry