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Protein Capped Metal Nanoparticles Inhibits Tau Aggregation in Alzheimer’s Disease

preprint
submitted on 31.05.2019 and posted on 31.05.2019 by Absar Ahmad, Subashchandrabose Chinnathambi
The Alzheimer’s disease (AD) therapeutic research is yielding large number of potent molecules. The nanoparticle-based therapeutics against the protein aggregation in AD is also taking a lead especially with amyloid beta as a primary target. In this work, we have screened for first time, the protein capped (PC) metal nanoparticles for their potency in inhibiting Tau aggregation in vitro. We present a novel function of PC-CdS nanoparticles as a potent Tau aggregation inhibitor by fluorescence spectrometry, SDS-PAGE and Electron microscopy. We demonstrate that the biologically synthesized PC-metal nanoparticles, iron oxide and cadmium sulphide do not affect the viability of neuroblastoma cells. Moreover, PC-CdS nanoparticles show dual property of inhibition as well as disaggregation of Tau. Thus, the nanoparticles can take a lead as potent Tau aggregation inhibitors and can be modified for specific drug delivery due to very small size. This current work presents unprecedented strategy to design anti-Tau aggregation drugs, which provides interesting insights to understand the role of biological nanostructures in Alzheimer’s disease.

Funding

(DBT-HDDB))-BT/PR/15780/MED/30/1629/2015

CSIR-National Chemical Laboratory grant MLP029526 and CSIR-network project BSC0115

History

Email Address of Submitting Author

s.chinnathambi@ncl.res.in

Institution

CSIR National Chemical Laboratory

Country

India

ORCID For Submitting Author

0000-0002-5468-2129

Declaration of Conflict of Interest

The authors declare no competing financial interest.

Version Notes

Protein Capped Metal Nanoparticles Inhibits Tau Aggregation in Alzheimer’s disease

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