ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files

Propargylic Alcohols as Three-Carbon Synthons in a Rhodium-Catalyzed Heteroannulation via a Merged C-H Functionalization and Cascade Cyclization Process

preprint
submitted on 15.02.2021, 06:03 and posted on 16.02.2021, 13:10 by Prajyot Nagtilak, Manmohan Kapur
We report herein, an unprecedented reactivity of propargyl alcohols as a “Three-Carbon Synthon” in the synthesis of core structures of isocryptolepine, g-carbolines, dihydrochromeno[2,3-b]indoles and diindolylmethane's (DIM) derivatives. The transformation involves a rhodium(III)-catalyzed C-H functionalization, heteroannulation of indoles followed by cascade cyclization with external as well as internal nucleophiles to afford diverse products. The reaction features highly effective transformations involving two C-C, two C-N and two C-O bonds, leading to the formation of a variety of molecular frameworks that are a part of several biologically active natural products.

Funding

SERB-India (EMR/2016/004298)

CSIR-India (02(0361)/19/EMR-II)

History

Email Address of Submitting Author

mk@iiserb.ac.in

Institution

Indian Institute of Science Education and Research Bhopal

Country

India

ORCID For Submitting Author

0000-0003-2592-6726

Declaration of Conflict of Interest

No conflict of Interest