These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
Mechanochemistry provides a highly efficient,
but still poorly understood route to synthesize and screen for polymorphs of
organic solids. We present a hitherto unexplored approach to control the
mechanism and outcome of mechanochemical cocrystallization through changes to
the milling assembly, i.e. milling jar and balls. Whereas polymorph
control of mechanochemical cocrystallization is typically discussed in terms of
liquid additives, real-time synchrotron X-ray diffraction studies reveal a
direct impact of the choice of milling media on the rate of formation and
interconversion of cocrystal polymorphs. This effect enabled the discovery of a
new polymorph of a cocrystal of nicotinamide and adipic acid, whose formation
and conversion to the previously known, enantiotropically-related form, was
readily controlled by milling in jars made of different materials.