These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Ni_PCCP.docx (585.17 kB)

Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide–Catalyzed Hydrosilylation of Terminal Epoxides

submitted on 03.10.2019, 18:44 and posted on 07.10.2019, 21:36 by Keri Steiniger, Tristan Lambert
The efficient and regioselective hydrosilylation of epoxides co-catalyzed by a pentacarboxycyclopentadienyl (PCCP) diamide nickel complex and Lewis acid is reported. This method allows for the reductive opening of terminal, monosubstituted epoxides to form unbranched, primary alcohols. A screen of diamide PCCP ligands revealed a correlation of steric demand and regioselectivity, with smaller ligands being optimal, while the addition of Lewis acid enabled efficient reactions at room temperature. A range of substrates including both terminal and non-terminal epoxides are shown to work, and a mechanistic rationale is provided. This work represents the first use of a PCCP derivative as a ligand for transition metal catalysis.


Catalytic Platforms Using Aromatic Ions and Other Charged Species

National Institute of General Medical Sciences

Find out more...


Email Address of Submitting Author


Cornell University


United States of America

ORCID For Submitting Author


Declaration of Conflict of Interest

no conflict of interest


Logo branding