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Predicting Nanoparticle Uptake by Biological Membranes: Theory and Simulation

preprint
submitted on 02.09.2020 and posted on 02.09.2020 by M. Schneemilch, N Quirke
We describe a new approach which predicts the level of internalisation or complete wrapping of nanoparticles by liposomes in solution. It is based on a generalisation of elastic theory to nanoscale particles with physical property data obtained from atomistic and coarse-grained simulations. We apply this approach to determine the maximum number of nanoparticles of a given type that can be internalised by a given liposome and give examples of how our approach might be used to identify and/or design nanoparticles with different uptakes: New data that could be correlated with nanoparticle toxicity experiments . We briefly discuss the possibility of designing nanoscale separations process.

Funding

EU Grant Agreement No. 686098, “Smartnanotox”

History

Email Address of Submitting Author

n.quirke@ic.ac.uk

Institution

imperial college

Country

UK

ORCID For Submitting Author

orcid.org/0000-0002-2528-7111

Declaration of Conflict of Interest

none

Version Notes

version two

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