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submitted on 02.09.2020 and posted on 02.09.2020by M. Schneemilch, N Quirke
We describe a new approach which predicts the level of internalisation or complete wrapping
of nanoparticles by liposomes in solution. It is based on a generalisation of elastic theory to
nanoscale particles with physical property data obtained from atomistic and coarse-grained
simulations. We apply this approach to determine the maximum number of nanoparticles of a
given type that can be internalised by a given liposome and give examples of how our
approach might be used to identify and/or design nanoparticles with different uptakes: New
data that could be correlated with nanoparticle toxicity experiments . We briefly discuss the
possibility of designing nanoscale separations process.