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DOShea preprint_update.pdf (3.93 MB)
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Potential for Release of Pulmonary Toxic Ketene from Vaping Pyrolysis of Vitamin E Acetate

preprint
revised on 27.11.2019 and posted on 06.12.2019 by Dan Wu, Donal O'Shea

The Centers for Disease Control and Prevention has recently reported an increasing number of clinically reported cases of lung injury following use of e-cigarette/vaping products. The cause(s) of this growing epidemic of vaping associated pulmonary injury remain unidentified, though vitamin E acetate has been recently identified as one possible causative agent (see Nature 574, 303 (2019). A combined analytical, theoretical and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in lung injuries associated with using some vaping products.

Funding

DW acknowledges the Synthesis and Solid State Pharmaceutical Centre (SSPC) for postdoctoral funding support

History

Email Address of Submitting Author

donalfoshea@rcsi.ie

Institution

RCSI

Country

Ireland

ORCID For Submitting Author

0000-0003-0594-4193

Declaration of Conflict of Interest

The authors declare no conflict of interest

Exports