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DOShea preprint_update.pdf (3.93 MB)

Potential for Release of Pulmonary Toxic Ketene from Vaping Pyrolysis of Vitamin E Acetate

revised on 27.11.2019, 20:33 and posted on 06.12.2019, 07:01 by Dan Wu, Donal O'Shea

The Centers for Disease Control and Prevention has recently reported an increasing number of clinically reported cases of lung injury following use of e-cigarette/vaping products. The cause(s) of this growing epidemic of vaping associated pulmonary injury remain unidentified, though vitamin E acetate has been recently identified as one possible causative agent (see Nature 574, 303 (2019). A combined analytical, theoretical and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in lung injuries associated with using some vaping products.


DW acknowledges the Synthesis and Solid State Pharmaceutical Centre (SSPC) for postdoctoral funding support


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Declaration of Conflict of Interest

The authors declare no conflict of interest