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Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

preprint
submitted on 19.11.2020, 07:12 and posted on 19.11.2020, 13:28 by Johannes Karges, Mickaël Tharaud, Gilles Gasser

The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances.

Funding

European Research Council

Agence Nationale de la Recherche

History

Email Address of Submitting Author

gilles.gasser@chimieparistech.psl.eu

Institution

Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences

Country

France

ORCID For Submitting Author

0000-0002-4244-5097

Declaration of Conflict of Interest

No conflict of interest

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