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Cobalt polymer archive.pdf (2.4 MB)

Polymer Endgroup Control Through a Trifunctional Cobalt-Mediated Radical Polymerization: New Avenues for Synthesising Protein Conjugates

preprint
submitted on 04.11.2020, 04:23 and posted on 04.11.2020, 10:20 by Meri Ayurini, Peter Chandler, David Rudd, Karen D. Milewska, Lara Malins, Ashley Buckle, Joel Hooper

Cobalt-mediated radical polymerisations (CMRPs) have been initiated by the radical decarboxylation of tetrachlorophthalimide activated esters. This allows for the controlled radical polymerisation of both activated and less activated monomers across a broad temperature range with a single cobalt species, with incorporation of polymer endgroups derived from simple carboxylic acids derivatives and termination with an organozinc reagent. This method has been applied to the synthesis of a water-soluble protein/polymer conjugate, demonstrating the first example of CMRP in protein conjugation.

History

Email Address of Submitting Author

Joel.hooper@monash.edu

Institution

Department of Chemistry, Monash University

Country

Australia

ORCID For Submitting Author

0000-0002-9941-2034

Declaration of Conflict of Interest

No conflict of interest

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