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Polymer Cyclization as a General Strategy for the Emergence of Hierarchical Nanostructures

revised on 18.12.2020, 09:17 and posted on 21.12.2020, 07:03 by Chaojian Chen, Manjesh Kumar Singh, Katrin Wunderlich, Sean Harvey, Manfred Wagner, George Fytas, Kurt Kremer, Debashish Mukherji, David Yuen Wah Ng, Tanja Weil
The creation of synthetic polymer nanoobjects with well-defined hierarchical structures is important for a wide range of applications such as nanomaterial synthesis, catalysis, and therapeutics. Inspired by the programmability and precise three-dimensional architectures of biomolecules, here wedemonstrate the strategy of fabricating controlled hierarchical structures through self-assembly of folded synthetic polymers. Linear poly(2-hydroxyethyl methacrylate) of different lengths are folded into cyclic polymers and their self-assembly into hierarchical structures is elucidated by various experimental techniques and molecular dynamics simulations. Based on their structural similarity, macrocyclic brush polymers with amphiphilic block side chains are synthesized, which can self-assemble into wormlike structures and higher-ordered networks. Our work points out the vital role of polymer folding in macromolecular self-assembly and establishes a versatile approach for constructing biomimetic hierarchical assemblies.


German Research Foundation SFB 1066 (A06)

Promotionskolleg Pharmaceutical Biotechnology of Ulm University funded by the state of Baden‒Württemberg

Canada First Research Excellence Fund (CFREF)


Email Address of Submitting Author


Max Planck Institute for Polymer Research



ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no competing interests

Version Notes

Version 2.0