ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
partial POx reduction upload.pdf (696.51 kB)
0/0

Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline)

preprint
submitted on 14.01.2018 and posted on 16.01.2018 by Maria Pfister, Annemarie Ringhand, Corinna Fetsch, Robert Luxenhofer
The partial reduction of poly(2-ethyl-2-oxazoline) was investigated. A series of poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s were synthesized by direct reduction using lithium aluminum hydride or borane/dimethylsulfide (BH3/DMS), respectively. It is shown that the degree of reduction can be readily controlled either by the reaction time when using an excess of LiAlH4 or by the stoichiometry of BH3/DMS as was demonstrated by 1H-NMR spectroscopy. Differential scanning calorimetry revealed that the glass transition temperature of the products decreased with increasing degree of reduction up to 25% of reduction, above which no glass transition could be detected. This control over the reduction allows the tailor synthesis of partially cationic polymers, which, in combination over the hydrophilic/lipophilic balance through the side chain length allows a tight control over materials properties. Such materials may be interesting, inter alia, for biomaterials or organic electronics.

History

Topic

  • Polyelectrolytes
  • Drug delivery systems

Email Address of Submitting Author

robert.luxenhofer@uni-wuerzburg.de

Institution

Julius-Maximilians-University Würzburg

Country

Germany

ORCID For Submitting Author

0000-0001-5567-7404

Declaration of Conflict of Interest

No conflict of interest

Exports