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Photoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-Amides to N-Fused Spirolactams

preprint
submitted on 25.06.2020 and posted on 29.06.2020 by Loïc Habert, Kevin Cariou
Using the spiro-cyclization of amides as a model reaction we have demonstrated that aerobic iodoarene catalysis can be enabled by relying on a pyrylium photocatalyst under blue light irradiation. This unprecedented dual organocatalytic system allows the use of low catalytic loading of both catalysts under very mild operating conditions.

Funding

This work was supported by a grant from the CNRS (Emergence@INC 2019 program)

History

Email Address of Submitting Author

kevin.cariou@cnrs.fr

Institution

Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences

Country

France

ORCID For Submitting Author

0000-0002-5854-9632

Declaration of Conflict of Interest

No conflict of interest

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