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Photoactivatable dihydroalkaloids for cancer theranostics with AIE characteristics

preprint
submitted on 02.06.2020 and posted on 08.06.2020 by Xia Ling, Letao Huang, Youzhen Li, Qing Wan, Zhiming Wang, Anjun Qin, Meng Gao, Ben Zhong Tang
Chemotherapeutics with systemic administration usually suffer from low treatment efficacy and off-target toxicity. In contrary, the photoactivatable cancer theranostics can achieve image-guided precise control of therapeutic dose and location. However, the conventional photoactivatable chemotherapeutics usually require decoration of chemotherapeutics with additional photo-responsive groups through tedious synthetic procedures, which can lead to undesirable toxic byproducts and seriously restrict their applications. Herein, we propose a new strategy for photoactivatable caner theranostics based on photooxidative dehydrogenation reaction, which is only associating with water as the byproduct. To demonstrate the power of this strategy, we utilized the natural dihydrobenzo[c]phenanthridine alkaloids of DHCHE and DHSAN as photoactivatable theranostics to achieve selective imaging and killing of cancer cells by in situ transformation into nucleus-targeted CHE and SAN under light irradiation. Notably, CHE is featured with aggregation-induced emission (AIE) characteristics, which can be used for precise control of the photoactivatable therapeutic dose. This photoactivatable strategy based on dihydroalkaloids is thus promising for precise cancer treatment in clinic.

Funding

This work was financially supported by the National Science Foundation of China (21788102, 51620105009, 21877040, 21602063, U1801252); the Science and Technology Planning Project of Guangzhou (201804020060, 201607020015 and 201704030069); Pearl River S&T Nova Program of Guangzhou (201806010152); Natural Science Foundation of Guangdong Province (2020B1515020010 and 2016A030312002); the Fundamental Research Funds for the Central Universities (2018JQ01); the Innovation and Technology Commission of Hong Kong (ITC-CNERC14SC01). The authors thank Dr. Bo Situ and Dr. Kaojin Wang’s kind help for cell imaging experiment.

History

Email Address of Submitting Author

msmgao@scut.edu.cn

Institution

South China University of Technology

Country

China

ORCID For Submitting Author

0000-0001-8071-8079

Declaration of Conflict of Interest

no conflict of interest

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