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Manuscript_Delasoie et al_FZ_ESI.pdf (6.31 MB)

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

submitted on 21.04.2020, 20:13 and posted on 23.04.2020, 05:38 by Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic, Fabio Zobi
Design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B12-photoactivable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells via transcobalamin (II) receptors and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation.


Swiss National Science Foundation, Grant PP00P2_170589

Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No.173048


Email Address of Submitting Author


Université de Fribourg



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest.